Pharmacomechanical Catheter-Directed Thrombolysis in Acute Femoral–Popliteal Deep Vein Thrombosis: Analysis from a Stratified Randomized Trial

Summary:  This article, published in Thrombosis and Haemostasis, describes the clinical outcomes of pharmaco-mechanical catheter-directed thrombolysis (PCDT) in the 300-patient subgroup of the ATTRACT study with femoral-popliteal deep vein thrombosis (DVT) (without involvement of more proximal veins).

Citation:
Kearon, Clive; Gu, Chu-Shu; Julian, Jim; Goldhaber, Samuel; Comerota, Anthony; Gornik, Heather; Murphy, Timothy; Lewis, Laurence; Kahn, Susan; Kindzelski, Andrei; Slater, Dennis; Geary, Randolph; Winokur, Ronald; Natarajan, Kannan; Dietzek, Alan; Leung, Daniel; Kim, Stanley; and Vedantham, Suresh, “Pharmacomechanical Catheter-Directed Thrombolysis in Acute Femoral-Popliteal Deep Vein Thrombosis: Analysis from a Stratified Randomized Trial”. Thromb Haemost. 2019. Paper 106. DOI: 10.1055/s-0039-1677795. PMID: 30699446

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Endovascular Thrombus Removal for Acute Iliofemoral Deep Vein Thrombosis: Analysis from a Stratified Multicenter Randomized Trial

Summary:  This article, published in Circulation, describes the clinical outcomes observed in the 391-patient subgroup of ATTRACT study patients who had iliofemoral DVT (DVT involving the iliac and/or common femoral vein).

Citation:
Comerota, Anthony J.; Kearon, Clive; Gu, Chu-Shu; Julian, Jim A.; Goldhaber, Samuel Z.; Kahn, Susan R.; Jaff, Michael R.; Razavi, Mahmood K.; Kindzelski, Andrei L.; Bashir, Riyaz; Patel, Parag; Sharafuddin, Mel; Sichlau, Michael J.; Saad, Wael E.; Assi, Zakaria; Hofmann, Lawrence V.; Kennedy, Margaret; and Vedantham, Suresh, “Endovascular Thrombus Removal for Acute Iliofemoral Deep Vein Thrombosis: Analysis from a Stratified Multicenter Randomized Trial”. Circulation. 2018. Paper 105. doi/10.1161/CIRCULATIONAHA.118.037425. PMID: 30586751.

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The Attract Trial: A Step Forward for Evidence Based DVT Care (Editorial 2018)

Summary:  This article, published in the European Journal of Endovascular and Vascular Surgery, contains additional perspective on the ATTRACT Trial from its lead investigator.

Citation:  Vedantham S. The Attract Trial: A Step Forward for Evidence Based DVT Care. Eur J Vasc Endovasc Surg. 2018 Sep; 56(3):320-321. doi: 10.1016/j.ejvs.2018.05.005. PMID: 29884439.

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Pharmacomechanical Therapy for Deep-Vein Thrombosis (Response Letter to NEJM Editor)

Summary:  This letter, published in the New England Journal of Medicine, is the lead investigators’ response to comments on the ATTRACT Trial’s main results.

Citation:  Vedantham S, Goldhaber SZ, Kearon C. Pharmacomechanical Therapy for Deep-Vein Thrombosis. N Engl J Med. 2018 May 3; 378(18):1752-1753. doi: 10.1056/NEJMc1802596. PMID: 29719183.

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Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis (ATTRACT Main Results)

Summary:  This article, published in the New England Journal of Medicine, describes the main results and primary outcome of the landmark ATTRACT Trial.

Citation:  Vedantham S, Goldhaber SZ, Julian JA, Kahn SR, Jaff MR, Cohen DJ, Magnuson E, Razavi MK, Comerota AJ, Gornik HL, Murphy TP, Lewis L, Duncan JR, Nieters P, Derfler MC, Filion M, Gu CS, Kee S, Schneider J, Saad N, Blinder M, Moll S, SacksD, Lin J, Rundback J, Garcia M, Razdan R, VanderWoude E, Marques V, Kearon C; ATTRACT Trial Investigators. Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis. N Engl J Med. 2017 Dec 7; 377(23):2240-2252. doi: 10.1056/NEJMoa1615066. PMID: 29211671.

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Rationale and design of the ATTRACT Study: A multicenter randomized trial to evaluate pharmacomechanical catheter-directed thrombolysis for the prevention of post thrombotic syndrome in patients with proximal deep vein thrombosis (ATTRACT Design Paper)

Summary:  This article, published in the American Heart Journal, summarizes the collaborative planning, methodology, and design of the ATTRACT Trial.

Citation:  Vedantham S, Goldhaber SZ, Kahn SR, Julian J, Magnuson E, Jaff MR, Murphy TP, Cohen DJ, Comerota AJ, Gornik HL, Razavi MK, Lewis L, Kearon C. Rationale and design of the ATTRACT Study: a multicenter randomized trial to evaluate pharmacomechanical catheter-directed thrombolysis for the prevention of postthrombotic syndrome in patients with proximal deep vein thrombosis. Am Heart J. 2013 Apr; 165(4):523-530.e3. doi: 10.1016/j.ahj.2013.01.024. PMID: 23537968; PMCID: PMC3612268.

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