Pharmacomechanical Catheter-Directed Thrombolysis in Acute Femoral–Popliteal Deep Vein Thrombosis: Analysis from a Stratified Randomized Trial
Summary: This article, published in Thrombosis and Haemostasis, describes the clinical outcomes of pharmaco-mechanical catheter-directed thrombolysis (PCDT) in the 300-patient subgroup of the ATTRACT study with femoral-popliteal deep vein thrombosis (DVT) (without involvement of more proximal veins).
Citation:
Kearon, Clive; Gu, Chu-Shu; Julian, Jim; Goldhaber, Samuel; Comerota, Anthony; Gornik, Heather; Murphy, Timothy; Lewis, Laurence; Kahn, Susan; Kindzelski, Andrei; Slater, Dennis; Geary, Randolph; Winokur, Ronald; Natarajan, Kannan; Dietzek, Alan; Leung, Daniel; Kim, Stanley; and Vedantham, Suresh, “Pharmacomechanical Catheter-Directed Thrombolysis in Acute Femoral-Popliteal Deep Vein Thrombosis: Analysis from a Stratified Randomized Trial”. Thromb Haemost. 2019. Paper 106. DOI: 10.1055/s-0039-1677795. PMID: 30699446
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Endovascular Thrombus Removal for Acute Iliofemoral Deep Vein Thrombosis: Analysis from a Stratified Multicenter Randomized Trial
Summary: This article, published in Circulation, describes the clinical outcomes observed in the 391-patient subgroup of ATTRACT study patients who had iliofemoral DVT (DVT involving the iliac and/or common femoral vein).
Citation:
Comerota, Anthony J.; Kearon, Clive; Gu, Chu-Shu; Julian, Jim A.; Goldhaber, Samuel Z.; Kahn, Susan R.; Jaff, Michael R.; Razavi, Mahmood K.; Kindzelski, Andrei L.; Bashir, Riyaz; Patel, Parag; Sharafuddin, Mel; Sichlau, Michael J.; Saad, Wael E.; Assi, Zakaria; Hofmann, Lawrence V.; Kennedy, Margaret; and Vedantham, Suresh, “Endovascular Thrombus Removal for Acute Iliofemoral Deep Vein Thrombosis: Analysis from a Stratified Multicenter Randomized Trial”. Circulation. 2018. Paper 105. doi/10.1161/CIRCULATIONAHA.118.037425. PMID: 30586751.
The Attract Trial: A Step Forward for Evidence Based DVT Care (Editorial 2018)
Summary: This article, published in the European Journal of Endovascular and Vascular Surgery, contains additional perspective on the ATTRACT Trial from its lead investigator.
Citation: Vedantham S. The Attract Trial: A Step Forward for Evidence Based DVT Care. Eur J Vasc Endovasc Surg. 2018 Sep; 56(3):320-321. doi: 10.1016/j.ejvs.2018.05.005. PMID: 29884439.
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Pharmacomechanical Therapy for Deep-Vein Thrombosis (Response Letter to NEJM Editor)
Summary: This letter, published in the New England Journal of Medicine, is the lead investigators’ response to comments on the ATTRACT Trial’s main results.
Citation: Vedantham S, Goldhaber SZ, Kearon C. Pharmacomechanical Therapy for Deep-Vein Thrombosis. N Engl J Med. 2018 May 3; 378(18):1752-1753. doi: 10.1056/NEJMc1802596. PMID: 29719183.
Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis (ATTRACT Main Results)
Summary: This article, published in the New England Journal of Medicine, describes the main results and primary outcome of the landmark ATTRACT Trial.
Citation: Vedantham S, Goldhaber SZ, Julian JA, Kahn SR, Jaff MR, Cohen DJ, Magnuson E, Razavi MK, Comerota AJ, Gornik HL, Murphy TP, Lewis L, Duncan JR, Nieters P, Derfler MC, Filion M, Gu CS, Kee S, Schneider J, Saad N, Blinder M, Moll S, SacksD, Lin J, Rundback J, Garcia M, Razdan R, VanderWoude E, Marques V, Kearon C; ATTRACT Trial Investigators. Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis. N Engl J Med. 2017 Dec 7; 377(23):2240-2252. doi: 10.1056/NEJMoa1615066. PMID: 29211671.
Rationale and design of the ATTRACT Study: A multicenter randomized trial to evaluate pharmacomechanical catheter-directed thrombolysis for the prevention of post thrombotic syndrome in patients with proximal deep vein thrombosis (ATTRACT Design Paper)
Summary: This article, published in the American Heart Journal, summarizes the collaborative planning, methodology, and design of the ATTRACT Trial.
Citation: Vedantham S, Goldhaber SZ, Kahn SR, Julian J, Magnuson E, Jaff MR, Murphy TP, Cohen DJ, Comerota AJ, Gornik HL, Razavi MK, Lewis L, Kearon C. Rationale and design of the ATTRACT Study: a multicenter randomized trial to evaluate pharmacomechanical catheter-directed thrombolysis for the prevention of postthrombotic syndrome in patients with proximal deep vein thrombosis. Am Heart J. 2013 Apr; 165(4):523-530.e3. doi: 10.1016/j.ahj.2013.01.024. PMID: 23537968; PMCID: PMC3612268.
Relationships between the use of pharmacomechanical catheter-directed thrombolysis, sonographic findings, and clinical outcomes in patients with acute proximal DVT: results from the ATTRACT multicenter randomized trial.
Summary: This article, published in Vascular Medicine, describes the ultrasound outcomes of pharmaco-mechanical catheter-directed thrombolysis (PCDT) in the ATTRACT study, and their relationship to clinical outcomes.
Citation:
Weinberg I, Vedantham S, Salter A, Hadley G, Al-Hammadi N, Kearon C, Julian JA, Razavi MK, Gornik HL, Goldhaber SZ, Comerota AJ, Kindzelski AL, Schainfeld RM, Angle JF, Misra S, Schor JA, Hurst D, Jaff MR, for the ATTRACT Trial Investigators. “Relationships between the use of pharmacomechanical catheter-directed thrombolysis, sonographic findings, and clinical outcomes in patients with acute proximal DVT: results from the ATTRACT multicenter randomized trial”. Vasc Med. 2019; 24(5):442-451. doi: 10.1177/1358863X19862043. PMCID: PMC6943930
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Cost-effectiveness of pharmacomechanical catheter-directed thrombolysis vs. standard anticoagulation in patients with proximal deep-vein thrombosis: results from the ATTRACT Trial.
Summary: This article, published in Circulation: Cardiovascular Quality and Outcomes, evaluates the costs and cost-effectiveness of pharmaco-mechanical catheter-directed thrombolysis (PCDT) in the ATTRACT study.
Citation:
Magnuson EA, Chinnakondepalli K, Vilain K, Kearon C, Julian JA, Kahn SR, Goldhaber SZ, Jaff MR, Kindzelski AL, Herman K, Brady PS, Sharma K, Black CM, Vedantham S, Cohen DJ. “Cost-effectiveness of pharmacomechanical catheter-directed thrombolysis vs. standard anticoagulation in patients with proximal deep-vein thrombosis: results from the ATTRACT Trial”. Circ Cardiovasc Qual Outcomes. 2019; 12(10):e005659. doi: 10.1161/CIRCOUTCOMES.119.005659. PMCID: PMC6788761
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Quality of life after pharmacomechanical catheter-directed thrombolysis for proximal deep vein thrombosis.
Summary: This article, published in the Journal of Vascular Surgery – Venous and Lymphatic Disorders, evaluates in detail the health-related quality of life of DVT patients treated, or not treated, with pharmaco-mechanical catheter-directed thrombolysis (PCDT) during the 2 years of follow-up.
Citation:
Kahn SR, Julian JA, Kearon C, Gu C, Cohen DJ, Magnuson EA, Comerota AJ, Goldhaber SZ, Jaff MR, Razavi MK, Kindzelski AL, Schneider JR, Kim P, Chaer R, Sista AK, McLafferty RB, Kaufman JA, Wible BC, Blinder M, Vedantham S, for the ATTRACT Trial Investigators. “Quality of life after pharmacomechanical catheter-directed thrombolysis for proximal deep vein thrombosis”. J Vasc Surg Venous Lymphat Disord. 2020. 8:8-23. doi: 10.1016/j.jvsv.2019.03.023. PMCID: Pending.
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External validation of the SOX-PTS score in a prospective multicenter trial of patients with proximal deep vein thrombosis.
Summary: In this article, published in the Journal of Thrombosis and Haemostasis, the authors utilize the ATTRACT Trial data-set to validate a new scoring system to be used for prediction of the development of post-thrombotic syndrome
Citation:
Rabinovich A, Gu CS, Vedantham S, Kearon C, Goldhaber SZ, Gornik HL, Kahn SR. “External validation of the SOX-PTS score in a prospective multicenter trial of patients with proximal deep vein thrombosis”. J Thromb Haemost. 2020. 18(6):1381-1389. doi: 10.1111/jth.14791. PMCID: PMC7545582. Pending
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Correlation between post-procedure residual thrombus and clinical outcome in deep vein thrombosis patients receiving pharmacomechanical thrombolysis in a multi-center randomized trial.
Summary: This article, published in the Journal of Vascular and Interventional Radiology, summarizes the venographic results of pharmaco-mechanical catheter directed thrombolysis (PCDT) and their relationship to long-term clinical outcomes.
Citation:
Razavi MK, Salter A, Goldhaber SZ, Lancia S, Kahn SR, Weinberg I, Kearon C, Azene EM, Patel NH, Vedantham S. “Correlation between post-procedure residual thrombus and clinical outcome in deep vein thrombosis patients receiving pharmacomechanical thrombolysis in a multi-center randomized trial”. J Vasc Interv Radiol. 2020. 31:1517-1528. doi: 10.1016/j.jvir.2020.07.010. PMCID: PMC7541749. Pending